My “gigs” were at church. I pretty much only played acoustic. Bedroom vs church were pretty much the same. We alway did a warm up/practice session prior to folks coming into the sanctuary. What you’re suggesting bedroom to live….. changes again when you have several hundred bodies sucking up the sound coming from the stage.
I never played any acoustic events as you describe.
I played on a church worship team back in 2012 for about a year for hire. It was more like a concert, playing for about 3,000 seated in a multi-tier arrangement, with 3 different performances each Sunday.
I never, ever changed my amp EQ settings. Whatever changes were made to the mix were done by the soundcrew.
Subsequently, i never change my EQ at any venue. My EQ is set to the tone that i like. I generally use grease pencil marks so the settings can always be replicated.
The only thing i change is the volume based on the size and dynamic of a given venue.
Now i have played with guys who fiddle with their amp on every song and they accomplish nothing but to become distracted, and even that's ok, on a personal level, because a lot of guys seem more into playing with gear than performing.
We've even made live recordings where the player couldn't hear the change in their constant tweaking, but they've convinced themselves they can hear the subtleties, and the fact they couldn't hear their constant changes in the recording upset them.
Playing medium size clubs, with a lot of drinking patrons, is an unbelievably noisy environment and playing with the amps at stage volume required having someone out in the back of the club to help us set the volume levels, but we never messed with EQ settings, only volume levels.