That's how I do it and sometimes the tiniest turn of the screw makes all the difference. For me its the overtones and also muddy wound strings on the neck pickup if they are too high.
On my guitars, the higher i go, the brighter and more clarity I get.
If I drop them, the output drops and they get muddy sounding.
On my Les Paul's I only use one pickup - the Epiphone version of the Gibson 498T/496R - known by Epiphone # as H8BN/H6BN.
After trying Virgil Arlo's, Thro-Baks, Seymour Duncan, Carvin, and Gibson's, I settled on the Epiphone based on the tip from Nicolas Chemsak.
Here's the specs on the Gibson 498T/496R:
Gibson 498T........................(Alnico5)..........................12.3 to 13.5kΩ
Gibson 496R........................(Ceramic)...........................8.3 to 8.6kΩ
And here are the specs on my favorite Epipphone pickups:
Epiphone HOTH8B...................(Ceramic8).........................13.14 to 14.4kΩ
Epiphone HB6N.........................(Alnico5)...............................8.12 to 8.60kΩ
Anything less than this and I want to throw the guitar away. It's just weak and dead sounding, even the revered Gibson T Top was muddy to my ears. Now, for some, that low output tone is golden, and that's cool, but it doesn't "happen" for me under about 14k, and I've spent a fortune learning this lesson.
Now, DiMarzio built me my custom humbucker that we called The Neanderthal. It is 16.5k Alnico 9 with 53mm spacing and nickel-silver baseplate.
It's almost a sonic match for an EMG81TW, but with greater clarity and articulation.
Look at this photo - the left waveform is EMG81TW and the right waveform (after the break) is the DiMarzio Neanderthal.
I had a 2015 Gibson Les Paul 50's Tribute with a 498T/496R and the Epiphone H8BN/H6BN sounds identical.
@Mitch Pearrow SJMP was at Primo studios in Riverside and heard me switch from Gibson to Epiphone pickups and he couldn't tell a difference, neither could my bandmates.
Since then, I've installed a bunch of these Epiphones for people who wanted an alternative to the 498T/496R with great results.