Definitely agree. Using the sample settings in the manual is an almost essential place to start, then tweak from there until you get used to how the controls interact with each other. Main thing for the Mesas (to me): as the gain goes up, the bass must go down.
Main reason I use a 50 watt/55Hz speaker. At over 1/2 volume, I can roll up a ton of bass and resonance and maintain total speaker clarity.
Our lead player complains that my 40 watt tube combo is louder than his Carvin full stack, but when he starts cranking it, the tone goes muddy regardless of EQ.
