I had a lot of dirt pedals when I had the Randall (which I rate highly) Diavlo, and I could not get any one of them to sound better than the overdriven Randall tone. I know what you're saying about dirt pedals not being of much use when you have a great overdrive amp channel.
I'm not saying that I'm going for this, but I need to think about cabs now... A 1x12 would need too much air pushing. I know the ENGL 1x10 I had before was very good and worth getting again. Or, and this may sound silly, a place locally are selling the Blackstar 4x8 (yes, I am stupid, I know...) for $200 - is that as stupid an idea as I think it might be; changing all four 8" speakers when they sound

e, and it still sounding

e? At least I know the 1x10 does sound good.